Scutellaria Barbata known and validated by science for cells protection, Immune Enhancement and Anti-Mutagenic activity.

Common Names:
Ban Zhi Lian, Barbed Skullcap

References:

Wong BY, Lau BH, Tadi PP, Teel RW: Chinese medicinal herbs modulate mutagenesis, DNA binding and metabolism of aflatoxin B1. Mutat Res 1992, 279(3):209-216.

Wong BY, Lau BH, Jia TY, Wan CP: Oldenlandia diffusa and Scutellaria barbata augment macrophage oxidative burst and inhibit tumor growth. Cancer Biother Radiopharm 1996, 11(1):51-56.

Wong BY, Lau BH, Teel RW: Chinese medicinal herbs modulate mutagenesis, DNA binding and metabolism of benzo[a]pyrene 7,8-dihydrodiol and benzo[a]pyrene 7,8-dihydrodiol-9,10-epoxide. Cancer Lett 1992, 62(2):123-131.

Wong BY, Lau BH, Yamasaki T, Teel RW: Inhibition of dexamethasone-induced cytochrome P4-mediated mutagenicity and metabolism of aflatoxin B1 by Chinese medicinal herbs. Eur J Cancer Prev 1993, 2(4):351-356.

Fong S, Shoemaker M, Cadaoas J, Lo A, Liao W, Tagliaferri M, Cohen I, Shtivelman E: Molecular mechanisms underlying selective cytotoxic activity of BZL101, an extract of Scutellaria barbata, towards breast cancer cells. Cancer Biol Ther 2008, 7(4):577-586.

Klawitter J, Klawitter J, Gurshtein J, Corby K, Fong S, Tagliaferri M, Quattrochi L, Cohen I, Shtivelman E, Christians U: Bezielle (BZL101)-induced oxidative stress damage followed by redistribution of metabolic fluxes in breast cancer cells: a combined proteomic and metabolomic study. Int J Cancer 2011, 129(12):2945-2957.

Perez AT, Arun B, Tripathy D, Tagliaferri MA, Shaw HS, Kimmick GG, Cohen I, Shtivelman E, Caygill KA, Grady D et al: A phase 1B dose escalation trial of Scutellaria barbata (BZL101) for patients with metastatic breast cancer. Breast Cancer Res Treat 2010, 120(1):111-118.

Wong BY, Nguyen DL, Lin T, Wong HH, Cavalcante A, Greenberg NM, Hausted RP, Zheng J: Chinese medicinal herb Scutellaria barbata modulates apoptosis and cell survival in murine and human prostate cancer cells and tumor development in TRAMP mice. Eur J Cancer Prev 2009, 18(4):331-341.